反应详情

A mixture of benzylamine (43.24 g) and methylene chloride (300 ml) is cooled with ice-water, and a solution of ethoxycarbonylacetyl chloride (29.63 g) in methylene chloride (150 ml) is added dropwise thereto. The mixture is stirred at the same temperature for 2 hours. The mixture is filtered to remove precipitates (benzylamine hydrochloride). The filtrate is washed with 2% hydrochloric acid and a saturated sodium chloride solution, dried and then evaporated to remove the solvent. The residue is recrystallized from a mixture of ether and n-hexane, whereby ethyl (N-benzylcarbamoyl)acetate (42.15 g) is obtained as colorless needles. Yield: 96.8%.

1. filtrationThe mixture is filtered
2. customto remove
3. customprecipitates (benzylamine hydrochloride)
4. washThe filtrate is washed with 2% hydrochloric acid
5. dry with materiala saturated sodium chloride solution, dried
6. customevaporated
7. customto remove the solvent
8. customThe residue is recrystallized from a mixture of ether and n-hexane