HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetonitrile → 1-(Pyridin-3-ylmethyl)piperidine-2,4-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetonitrile | HCID 6342 | — |
| Reactant | Methyl 1-(3-pyridylmethyl)-2,4-dioxopiperidine-3-carboxylate | HCID 20204023 | — |
| Solvent | Water | HCID 962 | — |
| Product | 1-(Pyridin-3-ylmethyl)piperidine-2,4-dione | HCID 13606578 | 100.6% |
Reaction Steps
A mixture of methyl 1-(3-pyridylmethyl)-2,4-dioxopiperidine-3-carboxylate (8.50 g), acetonitrile (100 ml) and water (1.4 ml) is refluxed for one hour. The mixture is distilled to remove the solvent to give 1-(3-pyridylmethyl)-2,4-dioxopiperidine (6.66 g, quantitative) as crystals, m.p. 55°-60° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04663319 |
| Source dataset | uspto-grants-1987_05 |
| ORD ID | ord-6c4481ce44f440ed844505fef675ea75 |
| Source note | uspto-grants-1987_05 |