Water → HCID 20204039, compound

Participants

Reaction Steps

Sodium (690 mg) is dissolved in ethanol (25 ml), and thereto is added dropwise a solution of ethyl[N-(p-nitrobenzyl)-N-(methoxycarbonylethyl)carbamoyl]acetate (10.0 g) in benzene (160 ml) at room temperature. The mixture was stirred at the same temperature for 1.5 hours. The mixture is poured into water. The aqueous layer is separated, neutralized with 10% HCl and extracted with ethyl acetate. The extract is washed with a saturated sodium chloride solution, dried and then distilled to remove the solvent to give ethyl 1-(p-nitrobenzyl)-2,4-dioxopiperidine-3-carboxylate (8.03 g, 88.4%) as yellow oil.

Provenance & Evidence