Ammonia → 1,1-dioxo-3-N-(7-piperidin-1-ylhept-5-ynyl)-1,2,5-thiadiazole-3,4-diamine

HRID 977988Notes

Reaction equation

HRID 977988 reaction equation
[N:1]1([CH2:7][C:8]#[C:9][CH2:10][CH2:11][CH2:12][CH2:13][NH2:14])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.CO[C:17]1[C:21](OC)=[N:20][S:19](=[O:25])(=[O:24])[N:18]=1.[NH3:26]>>[NH2:26][C:17]1[C:21]([NH:14][CH2:13][CH2:12][CH2:11][CH2:10][C:9]#[C:8][CH2:7][N:1]2[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]2)=[N:20][S:19](=[O:25])(=[O:24])[N:18]=1

Participants

4

Reactant 3

HCID 222AmmoniaHCID 122305383,4-Dimethoxy-1,2,5-thiadiazole 1,1-dioxideHCID 201476437-Piperidinohept-5-ynylamine

Product 1

HCID 1785093161,1-dioxo-3-N-(7-piperidin-1-ylhept-5-ynyl)-1,2,5-thiadiazole-3,4-diamine

Procedure

In a manner similar to Example 1, reaction of 7-piperidinohept-5-ynylamine and 3,4-dimethoxy-1,2,5-thiadiazole-1,1-dioxide followed by reaction with ammonia gives the title compound.

Sources & evidence

ORD record
ord-2856b006f7364abb8e98753a97427f03
Source dataset
uspto-grants-1987_05
Patent number
US04663331

Reaction notes

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