Beta-Alanine → HCID 13770335, compound

HRID 978053Notes

Reaction equation

HRID 978053 reaction equation
[NH2:1][CH2:2][CH2:3][C:4]([OH:6])=[O:5].[C:7](Cl)(=[O:12])[CH2:8][CH2:9][CH2:10][CH3:11].[OH-].[Na+]>O.CCOCC>[C:7]([NH:1][CH2:2][CH2:3][C:4]([OH:6])=[O:5])(=[O:12])[CH2:8][CH2:9][CH2:10][CH3:11]

Participants

6

Reactant 3

HCID 239Beta-AlanineHCID 14798Sodium HydroxideHCID 61186Valeryl chloride

Product 1

HCID 13770335HCID 13770335, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 3283Diethyl EtherSolvent

Procedure

β-Alanine (20 mmol) was reacted with valeryl chloride (22 mmol) in the presence of NaOH (40 mmol) in a mixture of H2O and ether using the method described in Example 5. The crude crystalline product (2.75 g, 79%) was recrystallized from a mixture of isopropyl ether (150 ml) and ethyl acetate (10 ml) to give title acid (1.51 g, 44%), m.p. 73°-76° C.

Workup

  1. customThe crude crystalline product (2.75 g, 79%) was recrystallized from a mixture of isopropyl ether (150 ml) and ethyl acetate (10 ml)
  2. customto give title acid (1.51 g, 44%), m.p. 73°-76° C.

Sources & evidence

ORD record
ord-5428a0afa66c400680c1e9196d80a012
Source dataset
uspto-grants-1987_05
Patent number
US04663336

Reaction notes

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