Hydrochloric Acid → HCID 20205029, compound

Participants

Reaction Steps

A mixture of 3-acetoxy-2-benzyl-5-chlorobenzo[b]thiophene (100 mg) and 2N aqueous sodium hydroxide (2 ml) in ethanol (1 ml) was heated at reflux temperature for 1 hour. The reaction mixture was cooled in an ice bath and acidifed with concentrated hydrochloric acid. The solid that separated out was collected by filtration, washed with water, and dried in vacuo over calcium sulfate to afford 2-benzyl-5-chloro-3-hydroxybenzo[b]thiophene as a white solid (40 mg); m/z 274 (M+.).

Provenance & Evidence