反应详情

A mixture of 2-(m-methylbenzylthio)-5-trifluoromethylbenzoic acid (1.65 g, 5.06 mmol) and 1-aza-2-methoxy-1-cycloheptene (643 mg, 5.06 mmol) was heated at 80°-85° C. for 18 hours, cooled, diluted with diethyl ether, washed with 1N aqueous sodium hydroxide solution, water, dried (sodium sulfate), and evaporated. The product was crystallized from methanol; yield 885 mg (51%). The 60 MHz NMR spectrum in chloroform-d was in accord with the desired structure.

1. temperaturewas heated at 80°-85° C. for 18 hours
2. temperaturecooled
3. washwashed with 1N aqueous sodium hydroxide solution, water
4. dry with materialdried (sodium sulfate)
5. customevaporated
6. customThe product was crystallized from methanol