Hydrochloric Acid → HCID 20205056, compound

Participants

Reaction Steps

A mixture of 3-acetoxy-5-chloro-2-phenylbenzo[b]thiophene (150 mg, 0.50 mmol) and 20% aqueous sodium hydroxide (5 ml) was stirred at reflux temperature for 1 hour. The cooled reaction mixture was acidified with concentrated hydrochloric acid, the solid that separated out filtered, washed with water, and dried in vacuo over phosphorous pentoxide. Recrystallization from cyclohexane afforded pure 5-chloro-3-hydroxy-2-phenylbenzo[b]thiophene; yield 35 mg (26%); m/z 275 (M+.).

Provenance & Evidence