Benzo(B)Thiophene → HCID 20205017, compound

HRID 978092Notes

Reaction equation

HRID 978092 reaction equation
S1C2C=CC=CC=2C=C1.[CH3:10][O:11][C:12]1[C:13]2[CH:24]=[C:23]([C:25]([F:28])([F:27])[F:26])[CH:22]=[CH:21][C:14]=2[S:15][C:16]=1[C:17]([O:19]C)=[O:18]>>[CH3:10][O:11][C:12]1[C:13]2[CH:24]=[C:23]([C:25]([F:28])([F:26])[F:27])[CH:22]=[CH:21][C:14]=2[S:15][C:16]=1[C:17]([OH:19])=[O:18]

Participants

3

Reactant 2

HCID 7221Benzo(B)ThiopheneHCID 20205028HCID 20205028, compound

Product 1

HCID 20205017HCID 20205017, compound

Procedure

When the starting benzothiophene of the above example was replaced by methyl 3-methoxy-5-(trifluoromethyl)benzo[b]thiophene-2-carboxylate, there was obtained 3-methoxy-5-(trifluoromethyl)-benzo[b]thiophene-2-carboxylic acid.

Sources & evidence

ORD record
ord-dfa77c561df14ae28b0436117a82c70d
Source dataset
uspto-grants-1987_05
Patent number
US04663344

Reaction notes

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