Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 978095Generated: October 26, 2026

Methyl 2-mercapto-5-trifluoromethylbenzoate → Methyl 3-(3-hydroxybenzo[b]thiophen-2-yl)acrylate

https://huagongshe.com/reaction/978095

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethyl 2-mercapto-5-trifluoromethylbenzoateHCID 13787739—
ReactantMethyl 3-(3-hydroxy-5-(trifluoromethyl)benzo[b]thiophene-2-yl)acrylateHCID 54728137—
Reactant2-sulfanylbenzoateHCID 178524318—
ProductMethyl 3-(3-hydroxybenzo[b]thiophen-2-yl)acrylateHCID 54738140—

Reaction Steps

When the starting thiosalicylate of the above example was replaced by 5-(trifluoromethyl)thiosalicyclic acid methyl ester, methyl 3-(3-hydroxy-5-(trifluoromethyl)benzo[b]thiophene-2-yl)acrylate, an off-white solid m/z 302 (M+.) was obtained.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04663344
Source datasetuspto-grants-1987_05
ORD IDord-571a939507694d5a825d7d6e951e4808
Source noteuspto-grants-1987_05