Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acetyl chloride | HCID 6367 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Ethyl 4-hydroxy-3-methyl-1-benzofuran-2-carboxylate | HCID 748649 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 790878 | HCID 790878 | — |
Reaction Steps
To a cold (0° C.) solution of ethyl-4-hydroxy-3-methylbenzofuran-2-carboxylate (2.2 g, 10 mmol) in dry THF (30 ml) was added triethylamine (2.07 ml, 15 mmol) followed by acetyl chloride (0.85 ml, 12 mmol). The mixture was stirred at 0° C. for 1 hour, and at room temperature for 2 hours, and was then poured into ice water (200 ml). The white precipitate was collected by filtration.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04663347 |
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| Source dataset | uspto-grants-1987_05 |
|---|
| ORD ID | ord-cfc156c7492d41b4a0e6f9c0712ad2ea |
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| Source note | uspto-grants-1987_05 |
|---|
