HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,4-Dichlorobenzene → Ethyl 5-allyl-4-hydroxy-3-methylbenzofuran-2-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,4-Dichlorobenzene | HCID 4685 | — |
| Reactant | Ethyl 4-allyloxy-3-methylbenzofuran-2-carboxylate | HCID 13849488 | — |
| Product | Ethyl 5-allyl-4-hydroxy-3-methylbenzofuran-2-carboxylate | HCID 13849523 | 85% |
Reaction Steps
A solution of ethyl 4-allyloxy-3-methylbenzofuran-2-carboxylate (1.04 g, 4 mmol, Example 116) in dichlorobenzene was refluxed for 3 hours. The resulting solution was chromatographed (silica gel, 5% ethyl acetate in hexane) to give 8.7 g of the title compound (85% yield), m.p. 123° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04663347 |
| Source dataset | uspto-grants-1987_05 |
| ORD ID | ord-9783708625d04cf3aece88f8b32303a7 |
| Source note | uspto-grants-1987_05 |