Sodium Hydroxide → HCID 13849537, compound

Participants

Reaction Steps

3-Chloro-4-methyl-6-chloro-7-hydroxycoumarin was refluxed with NaOH (30 ml, 1N) for 1 hour. The mixture was washed with three 50 ml portions of ethyl acetate. Then acidification (HCl, 3N) of the aqueous phase followed by filtration of the solid that precipitated gave 0.5 g (54% yield) of the desired acid, m.p. 279°-280° C. In the ethyl acetate extract 0.2 g of decarboxylate product was recovered as a by product,

Provenance & Evidence