HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → Ethyl (E)-3-(4-hydroxy-3-methylbenzofuran-2-yl)propenoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Ethyl Acrylate | HCID 8821 | — |
| Reactant | 3-Methyl-1-benzofuran-4-ol | HCID 11008068 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | Ethyl (E)-3-(4-hydroxy-3-methylbenzofuran-2-yl)propenoate | HCID 13849545 | 20.3% |
Reaction Steps
A mixture of 4-hydroxy-3-methylbenzofuran (2.9 g, 20 mmoles) palladium III acetate (4.5 g, 20 mmoles), ethyl acrylate (2 g, 20 mmoles), acetic acid (50 ml) and dioxane (200 ml) was refluxed for 3 hours. The mixture was filtered and the filtrate concentrated and chromatographed to obtain 1 g of the title compound after recrystallization from toluene, m.p. 180°-182° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04663347 |
| Source dataset | uspto-grants-1987_05 |
| ORD ID | ord-00559480ef0a4401be948920b4030b28 |
| Source note | uspto-grants-1987_05 |