Sodium ion → 6-Fluoro-5-[4-(5-fluoro-2,3-dihydrobenzofuran-7-yl)-2-hydroxy-4-methyl-2-trifluoromethyl-pentylamino]-2-methylquinoline

HRID 97812Notes

Reaction equation

HRID 97812 reaction equation
[C:36]([BH3-:37])#[N:38].[F:1][c:2]1[cH:3][c:4]([C:11]([CH2:12][C:13]([CH:14]=[O:15])([C:16]([F:17])([F:18])[F:19])[OH:20])([CH3:21])[CH3:22])[c:5]2[c:6]([cH:10]1)[CH2:7][CH2:8][O:9]2.[NH2:23][c:24]1[c:25]2[cH:26][cH:27][c:28]([CH3:35])[n:29][c:30]2[cH:31][cH:32][c:33]1[F:34].[Na+:39]>>[F:1][c:2]1[cH:3][c:4]([C:11]([CH2:12][C:13]([CH2:14][NH:23][c:24]2[c:25]3[cH:26][cH:27][c:28]([CH3:35])[n:29][c:30]3[cH:31][cH:32][c:33]2[F:34])([C:16]([F:17])([F:18])[F:19])[OH:20])([CH3:21])[CH3:22])[c:5]2[c:6]([cH:10]1)[CH2:7][CH2:8][O:9]2

Participants

5

Reactant 4

HCID 923Sodium ionHCID 498716Cyano-borohydrideHCID 128968136-Fluoro-2-methylquinolin-5-amineHCID 441849894-(2,3-Dihydro-5-fluoro-7-benzofuranyl)-2-hydroxy-4-methyl-2-trifluoromethyl-pentanal

Product 1

HCID 117056816-Fluoro-5-[4-(5-fluoro-2,3-dihydrobenzofuran-7-yl)-2-hydroxy-4-methyl-2-trifluoromethyl-pentylamino]-2-methylquinoline

Sources & evidence

ORD record
ord-3c94b004c6f347e89a6035619ff383fb
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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