HCID 13790039, compound → HCID 13787712, compound

HRID 978128Notes

Reaction equation

HRID 978128 reaction equation
[OH:1][C:2]1[C:7]([CH2:8][CH2:9][CH3:10])=[C:6]([O:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][C:17]2[NH:21][N:20]=[N:19][N:18]=2)[CH:5]=[CH:4][C:3]=1[C:22](=[O:24])[CH3:23].Br.Br[CH2:27][CH2:28][CH2:29][CH2:30][C:31]1[CH:32]=[N:33][CH:34]=[CH:35][CH:36]=1>>[OH:1][C:2]1[C:7]([CH2:8][CH2:9][CH3:10])=[C:6]([O:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][C:17]2[N:21]([CH2:27][CH2:28][CH2:29][CH2:30][C:31]3[CH:32]=[N:33][CH:34]=[CH:35][CH:36]=3)[N:20]=[N:19][N:18]=2)[CH:5]=[CH:4][C:3]=1[C:22](=[O:24])[CH3:23]

Participants

3

Reactant 2

HCID 13790039HCID 13790039, compoundHCID 178439680HCID 178439680, compound

Product 1

HCID 13787712HCID 13787712, compound

Procedure

1-[2-Hydroxy-3-propyl-4-[5-(1H-tetrazol-5-yl)pentyloxy]phenyl]ethanone was allowed to react with 3-(4-bromobutyl)pyridine hydrobromide according to procedure B and the product was purified by high pressure liquid chromatography to give 1-[2-hydroxy-3-propyl-4-[5-[1-[4-(3-pyridinyl)butyl]-1H-tetrazol-5-yl]pentyloxy]phenyl]ethanone, which is the N-1 isomer, and 1-[2-hydroxy-3-propyl-4-[5-[2-[4-(3-pyridinyl)butyl]-2H-tetrazol-5-yl]pentyloxy]phenyl]ethanone, which is the N-2 isomer.

Workup

  1. customthe product was purified by high pressure liquid chromatography

Sources & evidence

ORD record
ord-621310cd0ea64bca829707aeaf16f555
Source dataset
uspto-grants-1987_05
Patent number
US04663332

Reaction notes

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