HCID 13790039, compound → HCID 13787713, compound

HRID 978129Notes

Reaction equation

HRID 978129 reaction equation
[OH:1][C:2]1[C:7]([CH2:8][CH2:9][CH3:10])=[C:6]([O:11][CH2:12][CH2:13][CH2:14][C:15]2[NH:19][N:18]=[N:17][N:16]=2)[CH:5]=[CH:4][C:3]=1[C:20](=[O:22])[CH3:21].Br.Br[CH2:25][CH2:26][CH2:27][CH2:28][C:29]1[CH:30]=[N:31][CH:32]=[CH:33][CH:34]=1>>[OH:1][C:2]1[C:7]([CH2:8][CH2:9][CH3:10])=[C:6]([O:11][CH2:12][CH2:13][CH2:14][C:15]2[N:19]([CH2:25][CH2:26][CH2:27][CH2:28][C:29]3[CH:30]=[N:31][CH:32]=[CH:33][CH:34]=3)[N:18]=[N:17][N:16]=2)[CH:5]=[CH:4][C:3]=1[C:20](=[O:22])[CH3:21]

Participants

3

Reactant 2

HCID 13790039HCID 13790039, compoundHCID 178439674HCID 178439674, compound

Product 1

HCID 13787713HCID 13787713, compound

Procedure

1-[2-Hydroxy-3-propyl-4-[3-(1H-tetrazol-5-yl)propoxy]phenyl]ethanone was allowed to react with 3-(4-bromobutyl)pyridine hydrobromide according to procedure B and the product was purified by high pressure liquid chromatography to give 1-[2-hydroxy-3-propyl-4-[3-[1-[4-(3-pyridinyl)butyl]-1H-tetrazol-5-yl]propoxy]phenyl]ethanone, which is the N-1 isomer, and 1-[2-hydroxy-3-propyl-4-[3-[2-[4-(3-pyridinyl)butyl]-2H-tetrazol-5-yl]propoxy]phenyl]ethanone, which is the N-2 isomer.

Workup

  1. customthe product was purified by high pressure liquid chromatography

Sources & evidence

ORD record
ord-f7a3167f99e8494bbe1f633eddfa1c6b
Source dataset
uspto-grants-1987_05
Patent number
US04663332

Reaction notes

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