3-(Chloromethyl)pyridine hydrochloride → HCID 13787714, compound

HRID 978130Notes

Reaction equation

HRID 978130 reaction equation
[OH:1][C:2]1[C:7]([CH2:8][CH2:9][CH3:10])=[C:6]([O:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][C:17]2[NH:21][N:20]=[N:19][N:18]=2)[CH:5]=[CH:4][C:3]=1[C:22](=[O:24])[CH3:23].Cl.Cl[CH2:27][C:28]1[CH:29]=[N:30][CH:31]=[CH:32][CH:33]=1>>[OH:1][C:2]1[C:7]([CH2:8][CH2:9][CH3:10])=[C:6]([O:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][C:17]2[N:21]([CH2:27][C:28]3[CH:29]=[N:30][CH:31]=[CH:32][CH:33]=3)[N:20]=[N:19][N:18]=2)[CH:5]=[CH:4][C:3]=1[C:22](=[O:24])[CH3:23]

Participants

3

Reactant 2

HCID 233943-(Chloromethyl)pyridine hydrochlorideHCID 178439680HCID 178439680, compound

Product 1

HCID 13787714HCID 13787714, compound

Procedure

1-[2-Hydroxy-3-propyl-4-[5-(1H-tetrazol-5-yl)pentyloxy]phenylethanone was allowed to reacted with 3-(chloromethyl)pyridine hydrochloride according to procedure A and the product was purified by high pressure liquid chromatography to give 1-[2-hydroxy-3-propyl-4-[5-[1-(3-pyridinyl)methyl-1H-tetrazol-5-yl]pentyloxy]phenyl]-ethanone, which is the N-1 isomer, and 1-[2-hydroxy-3-propyl-4-[5-[2-(3-pyridinyl)methyl]-2H-tetrazol-5-yl]pentyloxy]phenyl]ethanone, which is the N-2 isomer.

Workup

  1. customthe product was purified by high pressure liquid chromatography

Sources & evidence

ORD record
ord-153ad55b0f17473b9a8d1c826411e01b
Source dataset
uspto-grants-1987_05
Patent number
US04663332

Reaction notes

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