3-(2-Bromoethyl)pyridine hydrobromide → 1-[2-hydroxy-3-propyl-4-[4-[1-[2-(3-pyridinyl)ethyl]-1H-tetrazol-5-yl]butoxy]phenyl]ethanone

Participants

Reaction Steps

1-[2-Hydroxy-3-propyl-4-[4-(1H-tetrazol-5-yl)butoxy]phenyl]ethanone was allowed to react with (3-(2-bromoethyl)pyridine hydrobromide according to procedure A and the product was purified by high pressure liquid chromatography to give 1-[2-hydroxy-3-propyl-4-[4-[1-[2-(3-pyridinyl)ethyl]-1H-tetrazol-5-yl]butoxy]phenyl]ethanone, which is the N-1 isomer, and 1-[2-hydroxy-3-propyl-4-[4-[2-[2-(3-pyridinyl)ethyl]-2H-tetrazol-5-yl]butoxy]phenyl]ethanone, which is the N-2 isomer.

Provenance & Evidence