HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methoxyphenol → 12-[(2-Methylacryloyl)amino]dodecanoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methoxyphenol | HCID 9015 | — |
| Reactant | Methacryloyl chloride | HCID 13528 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 12-Aminododecanoic Acid | HCID 69661 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 12-[(2-Methylacryloyl)amino]dodecanoic acid | HCID 19386585 | — |
Reaction Steps
The same procedure as described above is utilized with 5.4 g (0.052 mol) of methacryloyl chloride, 10 g (0.047 mol) of 12-aminododecanoic acid, 4.4 g (0.01 mol) of sodium hydroxide, and p-methoxyphenol in a mixed solvent (H2O:Dioxane=50:50) at 0°-5° C. Yield after recrystallized from ethyl acetate is 10 g (75%). Melting point 70.8°-72.4° C. NMR (DMSO-d6), 7.8 gamma (br s, 1H, NH), 5.5 gamma (br s, 1H, =CH2), 5.2 gamma (br s, 1H, =CH2), 3.0 gamma (t, 2H, NCH2), 2.1 gamma (t, 2H, CH2COOH), 1.7 gamma (s, 3H, CH3), 1.2 gamma (br s, 18H, (CH2)9).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04663409 |
| Source dataset | uspto-grants-1987_05 |
| ORD ID | ord-5574e915f19f430dbb848b869c0993c3 |
| Source note | uspto-grants-1987_05 |