Formaldehyde → HCID 13471156, compound

HRID 978202Notes

Reaction equation

HRID 978202 reaction equation
[CH:1]1([N:4]2[C:13]3[C:8](=[CH:9][C:10]([F:20])=[C:11]([N:14]4[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]4)[N:12]=3)[C:7](=[O:21])[C:6]([C:22]([OH:24])=[O:23])=[CH:5]2)[CH2:3][CH2:2]1.[CH2:25]=O>C(O)=O>[CH:1]1([N:4]2[C:13]3[C:8](=[CH:9][C:10]([F:20])=[C:11]([N:14]4[CH2:15][CH2:16][N:17]([CH3:25])[CH2:18][CH2:19]4)[N:12]=3)[C:7](=[O:21])[C:6]([C:22]([OH:24])=[O:23])=[CH:5]2)[CH2:2][CH2:3]1

Participants

4

Reactant 2

HCID 712FormaldehydeHCID 4654511,8-Naphthyridine-3-carboxylic acid, 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-

Product 1

HCID 13471156HCID 13471156, compound

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

A suspension of 1.3 g (4.0 mmole) of 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-1,8-naphthyridine-3-carboxylic acid, 13.3 ml of 37% formalin and 13.3 ml of 88% formic acid was refluxed for four hours. The resulting solution was evaporated in vacuo. The residue was suspended in aqueous ethanol, the resulting precipitate removed by filtration, washed with water and dried in vacuo to give 1.24 g of the title compound, mp 236°-237° C.

Workup

  1. temperaturewas refluxed for four hours
  2. customThe resulting solution was evaporated in vacuo
  3. customthe resulting precipitate removed by filtration
  4. washwashed with water
  5. customdried in vacuo

Sources & evidence

ORD record
ord-ab931c5a156a4aeca7482f7f84d59fdc
Source dataset
uspto-grants-1987_05
Patent number
US04663457

Reaction notes

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