HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 978217Generated: October 29, 2026
Acetone → 3-(4-Methoxyphenyl)-2,2-dimethylcyclopropane-1-carboxylic acid
https://huagongshe.com/reaction/978217
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acetone | HCID 180 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 1-Bromo-4-chloro-4-(4-methoxyphenyl)-3,3-dimethylbutan-2-one | HCID 20205346 | — |
| Product | 3-(4-Methoxyphenyl)-2,2-dimethylcyclopropane-1-carboxylic acid | HCID 22347515 | 69% |
Reaction Steps
100 ml of acetone are added to a solution of 35.3 g (0.882 mol) of sodium hydroxide in 317 ml of water. Then, at 25° C., 26.5 g (0.083 mol) of 4-bromo-2,2-dimethyl-1-chloro-1-(4-methoxyphenyl)-3-butanone are added dropwise. The mixture is stirred at 25° C. for a further 12 hours, poured onto water and extracted with methylene chloride. The aqueous phase is acidified and extracted again. 12.6 g (69% of theory) of 2,2-dimethyl-3-(4-methoxyphenyl)cyclopropanecarboxylic acid of melting point 115° C. are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04663465 |
|---|
| Source dataset | uspto-grants-1987_05 |
|---|
| ORD ID | ord-2fb10fdab92046158ddef63747c639f3 |
|---|
| Source note | uspto-grants-1987_05 |
|---|
