HRID978281

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID66678

6-Methyl-1,2,3,4-tetrahydroquinoline

C10H13N

HCID73895

Benzene, 1-fluoro-2-nitro-

C6H4FNO2

$结构：CN1CCN(C(=O)Nc2cc(F)ccc2N2CCc3ccccc32)CC1.O=C(O)/C=C\C(=O)O$

HCID70406853

未命名化合物

PRODUCTS

生成物

结构：Cc1ccc2c(c1)CCCN2c1ccccc1[N+](=O)[O-]

HCID21297656

未命名化合物

HCID21299250

未命名化合物

结构：Cc1cc2c3c(c1)C(N1CCN(C)CC1)=Nc1ccccc1N3CCC2

HCID21299254

未命名化合物

PROCEDURE

实验过程

Starting with 6-methyl-1,2,3,4-tetrahydroquinoline and 2-fluoronitrobenzene and following steps 1a to 1f of Example 2, one may obtain, in sequence, 6-methyl-1-(2-nitrophenyl)-1,2,3,4-tetrahydroquinoline, 1-(2-aminophenyl)-6-methyl-1,2,3,4-tetrahydroquinoline, N-[2-(6-methyl-1-phenyl)-1,2,3,4-tetrahydroquinolin-1-yl]-4-methyl-1-piperazine carboxamide, and 5-methyl-7-(4-methyl-1-piperazinyl)-2,3-dihydro-1H-quino[1,8-ab][1,5]benzodiazepine.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-45768024532242b3a21c64f0179b32b6
来源数据集: uspto-grants-1987_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04663453
来源说明: uspto-grants-1987_05

反应 SMILES

[CH3:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[NH:8][CH2:7][CH2:6][CH2:5]2.F[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[N+:19]([O-:21])=[O:20].[C:22](O)(=O)/[CH:23]=[CH:24]\[C:25](O)=O.[N:30]1([C:39]2[CH:44]=[CH:43][C:42](F)=[CH:41][C:40]=2[NH:46][C:47]([N:49]2[CH2:54][CH2:53][N:52]([CH3:55])[CH2:51][CH2:50]2)=O)[C:38]2[C:33](=[CH:34][CH:35]=[CH:36][CH:37]=2)[CH2:32][CH2:31]1>>[CH3:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[N+:19]([O-:21])=[O:20])[CH2:7][CH2:6][CH2:5]2.[NH2:30][C:38]1[CH:33]=[CH:34][CH:35]=[CH:36][C:37]=1[N:8]1[C:9]2[C:4](=[CH:3][C:2]([CH3:1])=[CH:11][CH:10]=2)[CH2:5][CH2:6][CH2:7]1.[CH3:22][C:23]1[CH:36]=[C:37]2[C:38]3=[C:25]([CH:24]=1)[C:47]([N:49]1[CH2:50][CH2:51][N:52]([CH3:55])[CH2:53][CH2:54]1)=[N:46][C:40]1[CH:41]=[CH:42][CH:43]=[CH:44][C:39]=1[N:30]3[CH2:31][CH2:32][CH2:33]2