Sodium Hydroxide → 2-[1-(Ethoxyimino)propyl]-3-hydroxy-5-(benzo[b]thien-4-yl)cyclohex-2-en-1-one

Participants

Reaction Steps

A solution of sodium hydroxide (0.15 g) in water (2 ml) and then ethoxyamine hydrochloride (0.37 g) were added to a solution of 3-hydroxy-5-(benzo[b]thien-5-yl)-2-propionylcyclohex-2-en-1-one (1.05 g) in ethanol/dimethylformamide (5:2 v/v; (70 ml). The mixture was stirred at room temperature for 12 hr, and was subsequently poured into water. the dried (MgSO4) diethyl ether extract was evaporated to give 2-[1-(ethoxyimino)propyl]-3-hydroxy-5-(benzo[b]thien-4-yl)cyclohex-2-en-1-one as a white solid, mp 76° C.

Provenance & Evidence