Hydrochloric Acid → HCID 136393657, compound

Participants

Reaction Steps

A mixture of 3-hydroxy-5-(benzo[b]furan-2-yl)-2-butyryl cyclohex-2-en-1-one (1.0 g), ethoxyamine hydrochloride (0.36 g), sodium acetate (0.3 g) and ethanol (100 ml) were stirred at room temperature for 12 hr. The mixture was poured into a very dilute aqueous hydrochloric acid solution which was then extracted with ether. Evaporation of the dried (MgSO4) organic fraction and purification of the residue by column chromatography over silica with dichloromethane elution gave 2-[1-(ethoxyimino)butyl]-3-hydroxy-5-(benzo[b]furan-2-yl)cyclohex-2-en-1-one as a yellow solid, mp 70° C.

Provenance & Evidence