HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 5-(chloromethyl)-2-phenyl-1,3-oxazolidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Benzaldehyde | HCID 240 | — |
| Reactant | Epichlorohydrin | HCID 7835 | — |
| Product | 5-(chloromethyl)-2-phenyl-1,3-oxazolidine | HCID 270701 | 20% |
Reaction Steps
According to Carter and Blattacharye [J. Amer. Chem. Soc 75, 2503 (1953)], D,L-carnitine is obtained by reacting benzaldehyde, epichlorohydrin and ammonia in an organic solvent, the reaction product 2-phenyl-5-chloromethyloxazolidine is isolated and said compound is subsequently transformed into D,L-carnitine according to known techniques, with a yield of 20-25%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04664852 |
| Source dataset | uspto-grants-1987_05 |
| ORD ID | ord-7005e47fe6954e10b169843c7524f5f6 |
| Source note | uspto-grants-1987_05 |