HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Nitrophenol → benzyloxycarbonyl-L-lysine amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Nitrophenol | HCID 980 | — |
| Reactant | Dicyclohexylcarbodiimide | HCID 10868 | — |
| Reactant | N-alpha-Benzyloxycarbonyl-L-lysine | HCID 75172 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | benzyloxycarbonyl-L-lysine amide | HCID 7020264 | — |
Reaction Steps
Na -t-butyloxycarbonyl-Ne -benzyloxycarbonyl-L-lysine was dissolved in ethyl acetate and esterified with p-nitrophenol using dicyclohexylcarbodiimide as a coupling agent. Sodium bicarbonate (10%) was added and the product extracted into the organic layer and crystallized from solution, then added to aqueous ammonium hydroxide to form Na -t-butyloxycarbonyl-Ne -benzyloxycarbonyl-L-lysine amide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04665054 |
| Source dataset | uspto-grants-1987_05 |
| ORD ID | ord-14bbdd6d54904e618df25400db7d786c |
| Source note | uspto-grants-1987_05 |