Acetic Anhydride → HCID 70430585, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2.84 g of (+)-cis-2-(4-methoxyphenyl)-3-hydroxy-5-[2-(dimethylamino)ethyl]-9-chloro-2,3-dihydro-1,5-benzothiazepin-4(5H)-one, 30 ml of acetic anhydride and 30 drops of pyridine is stirred at 100° C. for 4 hours. After the reaction is completed, the reaction mixture is evaporated under reduced pressure to remove solvent. Toluene is added to the residue, and the mixture is evaporated under reduced pressure to remove solvent. The residue is converted to its hydrochloride and recrystallized from a mixture of ethanol and ether. 3.02 g of (+)-cis-2-(4-methoxyphenyl)-3-acetoxy-5-[2-(dimethylamino)ethyl]-9-chloro-2,3-dihydro-1,5-benzothiazepin-4(5H)-one hydrochloride hydrate are obtained.

Provenance & Evidence