Acetic Anhydride → HCID 70430585, compound

HRID 978342Notes

Reaction equation

HRID 978342 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C@H:9]2[C@@H:15]([OH:16])[C:14](=[O:17])[N:13]([CH2:18][CH2:19][N:20]([CH3:22])[CH3:21])[C:12]3[CH:23]=[CH:24][CH:25]=[C:26]([Cl:27])[C:11]=3[S:10]2)=[CH:5][CH:4]=1.[C:28](OC(=O)C)(=[O:30])[CH3:29]>N1C=CC=CC=1>[OH2:2].[ClH:27].[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C@H:9]2[C@@H:15]([O:16][C:28](=[O:30])[CH3:29])[C:14](=[O:17])[N:13]([CH2:18][CH2:19][N:20]([CH3:22])[CH3:21])[C:12]3[CH:23]=[CH:24][CH:25]=[C:26]([Cl:27])[C:11]=3[S:10]2)=[CH:5][CH:4]=1

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 67941806HCID 67941806, compound

Product 1

HCID 70430585HCID 70430585, compoundYield 88.9%

Reagents, catalysts & solvents 1

HCID 1049PyridineCatalyst

Procedure

A mixture of 1.27 g of (-)-cis-2-(4-methoxyphenyl)-3-hydroxy-5-[2-(dimethylamino)ethyl]-9-chloro-2,3-dihydro-1,5-benzothiazepin-4-(5H)-one, 15 ml of acetic anhydride and 15 drops of pyridine is treated in the same manner as described in Example 4. 1.40 g of (-)-cis-2-(4-methoxyphenyl)-3-acetoxy-5-[2-(dimethylamino)ethyl]-9-chloro-2,3-dihydro-1,5-benzo-thiazepin-4(5H)-one hydrochloride hydrate are obtained.

Workup

  1. additionis treated in the same manner

Sources & evidence

ORD record
ord-e7c21d1b15c54898aa95c3328e7dcbd4
Source dataset
uspto-grants-1987_05
Patent number
US04665068

Reaction notes

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