Potassium Carbonate → HCID 70430585, compound

Participants

Reaction Steps

A mixture of 200 mg of (±)-cis-2-(4-methoxyphenyl)-3-acetoxy-9-chloro-2,3-dihydro-1,5-benzothiazepin-4(5H)-one, 84 mg of 2-(dimethylamino)ethyl chloride hydrochloride, 220 mg of powdered potassium carbonate and 10 ml of acetone is refluxed for 20 hours. After the reaction is completed, insoluble materials are removed by filtration. The filtrate is evaporated to remove solvent. The residue is converted to its hydrochloride and then recrystallized from methanol. 226 mg of (±)-cis-2-(4-methoxyphenyl)-3-acetoxy-5-[2-(dimethylamino)ethyl]-9-chloro-2,3-dihydro-1,5-benzothiazepin-4(5H)-one hydrochloride hydrate are obtained. Yield: 85%

Provenance & Evidence