1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride → HCID 14207562, compound

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Reaction Steps

A solution of 2-carboethoxyamino-4-nitro-6-ethyl-benzoic acid and 1-(3-dimethylaminopropyl)-3-ethylcarbodimide hydrochloride in anhydrous THF (25 ml) was stirred at room temperature for 21/2 hrs. The solution was evaporated by dryness and the residue partitioned between ethyl acetate and water. The ethyl acetate layer was dried over magnesium sulphate and evaporated to a solid. The solid was recrystallized from methylene chloride: petroleum ether to give the title compound, 2-ethoxy-5-ethyl-7-nitro-4H-3,1-benzoxazin-4-one, m.p. 106°-107° C., Ir. 1770, 1660, 1600, 1595, 1535, 1515 cm.

Provenance & Evidence