Ammonia → HCID 21279772, compound

HRID 978375Notes

Reaction equation

HRID 978375 reaction equation
[F:1][C:2]([F:21])([F:20])[CH2:3][NH:4][C:5](=S)[NH:6][C:7]1[CH:12]=[CH:11][N:10]=[C:9]([S:13][CH2:14][CH2:15][CH2:16][C:17]#[N:18])[N:8]=1.[NH3:22]>>[F:1][C:2]([F:21])([F:20])[CH2:3][N:4]=[C:5]([NH2:22])[NH:6][C:7]1[CH:12]=[CH:11][N:10]=[C:9]([S:13][CH2:14][CH2:15][CH2:16][C:17]#[N:18])[N:8]=1

Participants

3

Reactant 2

HCID 222AmmoniaHCID 21279752HCID 21279752, compound

Product 1

HCID 21279772HCID 21279772, compound

Procedure

A mixture of 4-[4-(3-[2,2,2-trifluoroethyl]thioureido)pyrimid-2-ylthio]butyronitrile (0.32 g.), saturated ethanolic ammonia (20 ml.) and yellow mercuric oxide (0.5 g.) was stirred at room temperature for 20 hours and then filtered and the filtrate evaporated to dryness. The residue was recrystallised from a mixture of acetone and petroleum ether (b.p. 60°-80°) to give 4-[4-(2-[2,2,2-trifluoroethyl]guanidino)pyrimid-2-ylthio]butyronitrile (0.29 g.), m.p. 137°.

Workup

  1. filtrationfiltered
  2. customthe filtrate evaporated to dryness
  3. customThe residue was recrystallised from a mixture of acetone and petroleum ether (b.p. 60°-80°)

Sources & evidence

ORD record
ord-a0374bea876d493ea52bb64c207a2e14
Source dataset
uspto-grants-1987_05
Patent number
US04665073

Reaction notes

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