1,1,1-Trifluoro-2-isothiocyanatoethane → HCID 20202842, compound

Participants

Reaction Steps

To a solution of 3-(4-aminopyrimid-2-ylmethylthio)propionitrile (1.7 g.) in acetonitrile (40 ml.) was added 2,2,2-trifluoroethylisothiocyanate (2 ml.) and the solution heated under reflux for 17 hours. The acetonitrile was evaporated in vacuo and the residue dissolved in EtOAc, treated with decolourising carbon, filtered and evaporated to give 3-[4-(3-[2,2,2-trifluoroethyl]thioureido)pyrimid-2-ylmethylthio]propionitrile as an orange solid, m.p. 108°-110°.

Provenance & Evidence