Ammonia → HCID 13883833, compound

HRID 978407Notes

Reaction equation

HRID 978407 reaction equation
[F:1][C:2]([F:24])([F:23])[CH2:3][NH:4][C:5](=S)[NH:6][C:7]1[CH:11]=[CH:10][N:9]([CH2:12][C:13]2[CH:21]=[CH:20][C:16]([C:17]([NH2:19])=[O:18])=[CH:15][CH:14]=2)[N:8]=1.[NH3:25]>CCO>[F:1][C:2]([F:24])([F:23])[CH2:3][N:4]=[C:5]([NH2:25])[NH:6][C:7]1[CH:11]=[CH:10][N:9]([CH2:12][C:13]2[CH:21]=[CH:20][C:16]([C:17]([NH2:19])=[O:18])=[CH:15][CH:14]=2)[N:8]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 54301007HCID 54301007, compound

Product 1

HCID 13883833HCID 13883833, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 4-(3-[3-(2,2,2-trifluoroethyl)thioureido]pyrazol-1-ylmethyl)benzamide (180 mg.) in EtOH saturated with ammonia (5 ml.) was added yellow mercuric oxide (380 mg.). The mixture was stirred at room temperature for 17 hours. The mixture was centrifuged, then the supernatant liquor was evaporated in vacuo to give 4-[3-(2-[2,2,2-trifluoroethyl]guanidino)pyrazol-1-ylmethyl]benzamide, m.p. 192° (from EtOH/petroleum ether (b.p. 60°-80°)).

Workup

  1. customthe supernatant liquor was evaporated in vacuo

Sources & evidence

ORD record
ord-daaf6eea5b9741969b99eb1b7e38c0cf
Source dataset
uspto-grants-1987_05
Patent number
US04665073

Reaction notes

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