反应详情

To a solution of 10.3 g of phosgene in 45 ml of toluene, the solution of 20.3 g of ethyl 2-methylaminomethyl-4-phenylbutyrate (described in example 1) in 19 ml of toluene was added over a period of 20 minutes. The mixture was stirred at room temperature for 4 hours and evaporated to dryness. The residue was stirred for 10 minutes with 100 ml of ether, the solids were filtered, the filtrates were evaporated to dryness and the residue was distilled under high vacuum to give N-methyl-N-(2-ethoxycarbonyl-4-phenylbutyl)carbamoyl chloride, bp 179°-189°/1 mm Hg.

1. customevaporated to dryness
2. stirringThe residue was stirred for 10 minutes with 100 ml of ether
3. filtrationthe solids were filtered
4. customthe filtrates were evaporated to dryness
5. distillationthe residue was distilled under high vacuum