反应详情

A mixture of 5 parts of 1-acetyl-4-[2-(4-fluorophenyl)-1,3-dioxolan-2-yl]piperidine and 100 parts of a sodium hydroxide solution 10% was stirred and refluxed overnight. The reaction mixture was cooled and the product was extracted with trichloromethane. The extract was dried, filtered and evaporated. The solid residue was stirred in 2,2'-oxybispropane. The product was filtered off and dried in vacuo at 40° C., yielding 3.5 parts (82%) of 4-[2-(4-fluorophenyl)-1,3-dioxolan-2-yl]piperidine (2).

1. temperaturerefluxed overnight
2. temperatureThe reaction mixture was cooled
3. extractionthe product was extracted with trichloromethane
4. customThe extract was dried
5. filtrationfiltered
6. customevaporated
7. stirringThe solid residue was stirred in 2,2'-oxybispropane
8. filtrationThe product was filtered off
9. customdried in vacuo at 40° C.