HCID 20202868, compound → HCID 20202886, compound

Participants

Reaction Steps

A mixture of 25 parts of ethyl 2-nitro-4-(phenylmethoxy)benzoate and 160 parts of ethanol was hydrogenated at normal pressure and at room temperature with 5 parts of Raney-nickel catalyst. After the calculated amount of hydrogen was taken up, the catalyst was filtered off and the filtrate was evaporated. The residue was purified by column chromatography over silica gel using a mixture of trichloromethane and methanol (95.5 by volume) as eluent. The pure fractions were collected and the eluent was evaporated. The residue was boiled in 2,2'-oxybispropane. After cooling, the product was filtered off and dried, yielding 14.5 parts (65%) of ethyl 2-amino-4-(phenylmethoxy)benzoate (4).

Provenance & Evidence