HCID 12421797, compound → HCID 13851171, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of 28 parts of [1-(4-aminobutyl)-4-piperidinyl](4-fluorophenyl)methanone in 135 parts of tetrahydrofuran was added dropwise during a 10 minutes-period a solution of 24 parts of methyl 2-isothiocyanato-4-nitrobenzoate in 180 parts of tetrahydrofuran (slightly exothermic reaction). Upon completion, stirring was continued overnight at room temperature. The solid was filtered off and crystallized from ethanol while stirring and cooling to 40° C. The product was filtered off, washed with ethanol and dried in vacuo at 80° C., yielding 30 parts (62%) of 3-[4-[4-(4-fluorobenzoyl)-1-piperidinyl]butyl]-2,3-dihydro-7-nitro-2-thioxo-4(1H)-quinazolinone; mp. 225° C. (20).

Provenance & Evidence