Hydrogen Peroxide → HCID 13851175, compound

Participants

Reaction Steps

To a stirred mixture of 7 parts of 3-[2-[4-(4-fluorobenzoyl)-1-piperidinyl]ethyl]-2,3-dihydro-7-nitro-2-thioxo-4(1H)-quinazolinone, 120 parts of a solution of potassium hydroxide in ethanol 5% and 10 parts of water were added dropwise 100 parts of a hydrogen peroxide solution 3% during a 10 minutes period. Upon completion, stirring was continued for 2.50 hours at room temperature. Then there were added 100 parts of water and the whole was neutralized with acetic acid. The precipitated product was filtered off and crystallized from a mixture of N,N-dimethylacetamide and water, yielding 4.8 parts of 3-[2-[4-(4-fluorobenzoyl)-1-piperidinyl]ethyl]-7-nitro-2,4(1H,3H)-quinazolinedione; mp. 238.1°-240.1° C. (23).

Provenance & Evidence