Hydrogen Peroxide → HCID 13851172, compound

Participants

Reaction Steps

To a stirred mixture of 36 parts of 3-[4-[4-(4-fluorobenzoyl)-1-piperidinyl]butyl]-2,3-dihydro-7-nitro-2-thioxo-4(1H)-quinazolinone, 700 parts of a potassium hydroxide solution in ethanol 5% and 150 parts of water were added 500 parts of a hydrogen peroxide solution 3% at room temperature. The whole was stirred overnight at room temperature. The mixture was neutralized with acetic acid. The product was filtered off, washed with water and 2-propanol and stirred in 2,2'-oxybispropane and thrichloromethane. The product was filtered off and dried, yielding 31 parts (88%) of 3-[4-[4-(4-fluorobenzoyl)-1-piperidinyl]butyl]-7-nitro-2,4(1H,3H)-quinazolinedione; mp. 188° C. (24).

Provenance & Evidence