HCID 15257492, compound → HCID 13851179, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 12.5 parts of ethyl 2-(ethoxycarbonylamino)-5-hydroxybenzoate and 12 parts of 4-(1H-indol-3-yl)-1-piperidineethanamine was stirred in an oil bath at about 200° C. and under nitrogen atmosphere. The formed ethanol was distilled off. The whole was cooled and the solid product was crystallized from a mixture of ethanol and acetonitrile. The product was filtered off and dried, yielding 14.5 parts (70%) of 6-hydroxy-3-[2-[4-(1H-indol-3-yl)-1-piperidinyl]ethyl]-2,4(1H,3H)-quinazolinedione; mp. 258.2° C. (compound 1).

Provenance & Evidence