Potassium Hydroxide → HCID 20202872, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 9.3 parts of ethyl [2-[[[2-[4-(4-fluorobenzoyl)-1-piperidinyl]ethyl]amino]carbonyl]-4-(phenylmethoxy)phenyl]carbamate and 100 parts of a potassium hydroxide solution 10% in water was stirred in an oil-bath for 8 hours at 100° C. After cooling to room temperature, the precipitated product was filtered off, dried and boiled in 16 parts of methanol. Upon cooling to room temperature, the precipitated product was filtered off and dried in vacuo at 50° C., yielding 7.05 parts (83%) of 3-[2-[4-(4-fluorobenzoyl)-1-piperidinyl]ethyl]-6-(phenylmethoxy)-2,4-(1H,3H)-quinazolinedione (4).

Provenance & Evidence