Ammonia → HCID 13851197, compound

Participants

Reaction Steps

A mixture of 1.9 parts of 3-[4-[4-[2-(4-fluorophenyl)-1,3-dioxolan-2-yl]-1-piperidinyl]butyl]-7-hydroxy-2,4(1H,3H)-quinazolinedione, 10 parts of a hydrochloric acid solution 6N and 20 parts of ethanol was stirred for 4 hours at reflux temperature. The base was liberated with ammonia. The product was filtered off and purified by column chromatography over silica gel using a mixture of trichloromethane and methanol (90:10 by volume) as eluent. The pure fractions were collected and the eluent was evaporated, yielding 0.5 parts (28%) of 3-[4-[4-(4-fluorobenzyl)-1-piperidinyl]butyl]-7-hydroxy-2,4(1H,3H)-quinazolinedione; mp. 207.9° C. (27).

Provenance & Evidence