Sodium borohydride → HCID 20203303, compound

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Reaction Steps

2-(4-Oxopentyl)thiophene (3.30 g, 19.6 mmol) was dissolved in 10 ml of 95% ethanol and the solution was added to a stirred solution of sodium borohydride (0.38 g, 10 mmol) in 20 ml of ethanol at room temperature. The mixture was stirred overnight and the excess reducing agent destroyed by the dropwise addition of 1N HCl. The solvents were evaporated and the residue partitioned between water and ether. The organic phase was washed with water and brine and dried (Na2SO4) Evaporation of the solvents gave 3.13 g of product as a yellow oil, which was used without purification in the next step.

Provenance & Evidence