N-Carbethoxyphthalimide → HCID 21784644, compound

HRID 978464Notes

Reaction equation

HRID 978464 reaction equation
[C:1]([N:6]1[C:10](=[O:11])[C:9]2=[CH:12][CH:13]=[CH:14][CH:15]=[C:8]2[C:7]1=[O:16])(OCC)=O.[S:17]1[CH:21]=[CH:20][CH:19]=[C:18]1[CH2:22]CN>C(O)C>[S:17]1[CH:21]=[CH:20][CH:19]=[C:18]1[CH2:22][CH2:1][N:6]1[C:7](=[O:16])[C:8]2=[CH:15][CH:14]=[CH:13][CH:12]=[C:9]2[C:10]1=[O:11]

Participants

4

Reactant 2

HCID 31187N-CarbethoxyphthalimideHCID 116521Thiopheneethanamine

Product 1

HCID 21784644HCID 21784644, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

N-Carboethoxyphthalimide (4.93 g, 22.5 mmol) was added to a solution of 2-(2-thienyl)ethylamine (2.75 g, 21.6 mmol) in ethanol (20 ml) and was stirred for 20-25 hours. The precipitated product was collected by filtration, washed with cold methanol and dried. The product obtained (5.45 g) was used in the next step without purification.

Workup

  1. filtrationThe precipitated product was collected by filtration
  2. washwashed with cold methanol
  3. customdried
  4. customThe product obtained (5.45 g)
  5. customwas used in the next step without purification

Sources & evidence

ORD record
ord-8dc74f6b5f464108b1c95d51bb0e3d9d
Source dataset
uspto-grants-1987_05
Patent number
US04665090

Reaction notes

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