Acetyl chloride → HCID 70351280, compound

Participants

Reaction Conditions

Reaction Steps

The residue from Example 1, Step A (2.55 g, 6.3 mmol) was dissolved in pyridine (10 ml), cooled to -15° C. and acetyl chloride (547 mg, 6.9 mmol) was added. The mixture was stirred at 0° C. for 3 hours then at room temperature overnight. The solvent was removed in vacuo. To the residue, dil. Na2CO3 solution was added (30 ml) and the mixture was extracted with CHCl3 (50 ml then 20 ml). The combined CHCl3 extracts were washed with H2O (30 ml), dried over Na2SO4 and evaporated in vacuo. The residue was used directly in the next step without further purification.

Provenance & Evidence