Water → HCID 20203319, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred mixture of 0.312 mole methoxyamine hydrochloride in cooled (to about 0° C.) water, 0.312 mole potassium carbonate was added in portions; the temperature of the reaction mixture was maintained at about 0° C. during the addition. To that cool mixture, 0.25 mole benzoyl chloride dissolved in methylene chloride (about 300 ml) was added dropwise over about 0.5 hours. The temperature of the reaction mixture was kept at about 0 to 10° C. for the first hour; the reaction mixture was then allowed to come to room temperature and was stirred overnight. The layers were phase separated. The methylene chloride layer was dried over magnesium sulfate and then stripped. The residue was washed with cold ethyl ether/hexane to give the above-identified product as an off-white solid, melting point 58-60° C.

Provenance & Evidence