反应详情

1.00 g (3.69 mmole) 7-chloro-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-1,8-napthyridine-3-carboxylic acid, 40 ml acetonitrile, and 1.27 g (11.08 mmole) N-methyl3-pyrrolidinemethanamine are stirred at room temperature for three days. The reaction was filtered and the precipitate dissolved in aqueous ammonium hydroxide at pH 11. The solution was filtered and the solvent removed at reduced pressure. The product was washed with 5 ml of water, 10 ml ethanol/ether (1:1), and finally with ether until dry to give 0.571 g of 1-ethyl-6-fluoro-1,4-dihydro-7-[3-[(methylamino)-methyl]-1-pyrrolidinyl]-4-oxo-1,8-naphthyridine-3-carboxylic acid, mp 251°-253° C.

1. filtrationThe reaction was filtered
2. dissolutionthe precipitate dissolved in aqueous ammonium hydroxide at pH 11
3. filtrationThe solution was filtered
4. customthe solvent removed at reduced pressure
5. washThe product was washed with 5 ml of water, 10 ml ethanol/ether (1:1)
6. dry with materialfinally with ether until dry