1-Ethyl-6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid → 1-Ethyl-6,8-difluoro-1,4-dihydro-7-(7-ethyl-2,7-diazaspiro[4.4]non-2-yl)-4-oxo-3-quinolinecarboxylic acid
Reaction equation
[CH2:1]([N:3]1[C:12]2[C:7](=[CH:8][C:9]([F:15])=[C:10](F)[C:11]=2[F:13])[C:6](=[O:16])[C:5]([C:17]([OH:19])=[O:18])=[CH:4]1)[CH3:2].Cl.Cl.[CH2:22]([N:24]1[CH2:28][CH2:27][C:26]2([CH2:32][CH2:31][NH:30][CH2:29]2)[CH2:25]1)[CH3:23]>>[CH2:1]([N:3]1[C:12]2[C:7](=[CH:8][C:9]([F:15])=[C:10]([N:30]3[CH2:31][CH2:32][C:26]4([CH2:27][CH2:28][N:24]([CH2:22][CH3:23])[CH2:25]4)[CH2:29]3)[C:11]=2[F:13])[C:6](=[O:16])[C:5]([C:17]([OH:19])=[O:18])=[CH:4]1)[CH3:2]Participants
3
Procedure
The title compound was prepared according to example 26 by reacting 1-ethyl-6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid with 2-ethyl-2,7-diazaspiro[4.4]nonane dihydrochloride, mp 199°-202° C. (dec).
Sources & evidence
- ORD record
- ord-aca7c8143bdc4cc79cd5fce40eea64f6
- Source dataset
- uspto-grants-1987_05
- Patent number
- US04665079
Reaction notes
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