HCID 20203459, compound → HCID 70441207, compound

Participants

Reaction Conditions

Reaction Steps

27.0 g of 3-[2-(2-aminoethyl)-amino-5-nitrophenylsulphonyl]-propionic acid are suspended in 150 ml of water and 150 ml of ethanol. In an autoclave 1 g of nickel is added to the suspension, 60-70 bar of hydrogen are injected, and the temperature is raised to 60° C. Stirring is continued for some time until no further hydrogen is absorbed. After letting down, the resultant solution is clarified at 70° C. with 1 g of activated charcoal, the clarification residue is washed with 20 ml of hot water, and the combined filtrates are reacted as per Example 10.

Provenance & Evidence